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N/Rx® - Natural Products Validated to Prescription Standards Innovative, Accelerated and Cost-effective Development of Prescription, OTC and Nutraceutical Products - From natural plants - Effective - Safe - Validated to Prescription levels in - Chemistry Biological Studies Pharmacology Toxicology Phase I and II Clinical Studies Mechanism of Action Analytical Method Validation No microbial contamination, pesticide residues or heavy metals -Good Manufacturing Practices The average cost of bringing a new prescription (Rx) drug from concept to market has risen steadily over the last decade from $403 Million in 2000 to $899 Million in 2005 to $1.3 Billion in 2010 (Tufts Center for Study of Drug Development CSDD, Pharmaceutical Research and Manufacturers of America, April 2011). At the same time, the US FDA approvals of these Rx drugs, biological products and devices has consistently gone down from 160 in 2000 to 18 in 2007 and only 21 in 2010. And the benefits of these Rx drugs are often overshadowed by their significant side effects. Some of the biggest block buster drugs of all times came from plants. To name a few Aspirin from the willow tree, Atropine from Belladonna, Quinine from Cinchona, Digitalis from Foxglove and Taxol from the Pacific Yew tree. Over a period of time, and especially to address the challenges of supply and demand, all of these were synthesized in the laboratory, making them widely available and in some cases, more affordable. With synthesis came the risks of toxicity, similar to other synthetic chemical drugs. To escape from these safety issues, in recent years, consumers have turned to dietary supplements and nutraceuticals which are gaining huge popularity worldwide. However, these are most often developed using traditional methods and lack the scientific validation and documented safety and efficacy of the Rx chemical entities. Hence, there is a tremendous need for scientifically validated products that combine the safety of natural compounds and yet are validated to meet the rigorous requirements of testing and manufacture to prescription standards. Bioved's research focus capitalizes on 4,000 years of Ayurvedic medicine to identify candidates for novel phyto-pharmaceuticals. Ayurveda is a well documented science that has been in actual practice all through the centuries; and in wider acceptance in recent times. It has contributed several key pharmaceutical drugs to modern medicine. Notable among those are Reserpine for hypertension and Vincristine and Vinblastine in cancer chemotherapy. Over the last 12 years, Bioved has worked systematically on harnessing the knowledge of Ayurveda, developing and documenting research processes and methodologies; and discovering novel and unique plant-based phyto-pharmaceuticals, OTC products and nutraceuticals mainly targeted towards "Disorders of the Aging Population'. Our proprietary N/Rx® Platform has been strengthened by repeated proof of validation of safety and efficacy of the products developed. We have the experience and keen understanding to identify bio-active compounds and fractions, and create products with a strong and unique position in the bio-pharmaceutical markets. These products address the inherent need of the consumer of improving their ‘Quality of Life’. Over the the last decade we have met with recurring success on various products. We have a fully integrated model of “Discovery Engine” and highly cost-effective contract research capabilities in India. We have built up a unique core competency with repeated proof of concept in developing and validating plant-based, safe and effective products that address ‘difficult to treat diseases’. |
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